Advanced treatment options for depression when traditional approaches haven’t provided enough relief.
Ketamine is a medication that has been used in medical settings for decades, including anesthesia and pain management. Today, it is also being used under medical supervision as part of treatment approaches for certain mental health conditions, particularly for people who have not found adequate relief with traditional treatments.
For some patients, ketamine may help improve symptoms of depression, anxiety, PTSD, and OCD more quickly than traditional antidepressant medications. The duration and degree of benefit vary from person to person, and treatment is carefully monitored by qualified medical professionals.
Ketamine is a Schedule III medication in the United States and is administered legally under appropriate medical supervision. Its established use in anesthesia and other medical settings provides a substantial history of clinical experience with the medication.
When combined with intentional ketamine-assisted psychotherapy, ketamine treatment may also provide an opportunity to explore emotional and psychological patterns while the effects of the medication are present. Treatment plans are individualized based on each patient’s needs, medical history, and clinical goals.
A prescription nasal spray approved for treatment-resistant depression and major depressive disorder with suicidal thoughts or actions.
May be a good option if you've tried two or more antidepressants without sufficient relief, have ongoing depressive symptoms despite treatment, or want a medically supervised, insurance-friendly option.
Spravato® uses only the S-enantiomer of ketamine, FDA-approved for treatment-resistant depression. It's often covered by insurance and must be used alongside an oral antidepressant.
Treatments happen in our office with at least two hours of monitoring post-administration. Patients typically start twice-weekly for the first month, then taper based on progress.
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IV ketamine is delivered through a controlled infusion under medical supervision. Ketamine affects glutamate pathways in the brain and may influence neural connectivity and brain signaling. Your clinician determines the appropriate treatment approach based on your individual needs and medical history.
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Treatment takes place in a comfortable clinical setting with your care team present. Your clinician will guide you through the infusion and recovery process while monitoring your response. Temporary effects such as dizziness, drowsiness, nausea, or changes in perception may occur.
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Your vital signs and response to treatment are monitored throughout the session by a qualified clinician. The infusion may be adjusted based on your response, and treatment can be paused or stopped when medically appropriate.
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IV ketamine and SPRAVATO® (esketamine) are different treatment options with different methods of administration. SPRAVATO® is an FDA-approved nasal spray for specific indications, while IV ketamine is used off-label. Treatment protocols and insurance coverage may vary.
per treatment
for 6 treatment
induction series
Generally recommended based on established treatment protocols.
Learn More about the science and research behind Ketamine Therapy through the ASPK Scientific Literature
Intravenous ketamine therapy provided in a private, comfortable setting under medical supervision. IV ketamine may be considered for patients with treatment-resistant depression, anxiety, PTSD, or other conditions when traditional treatments have not provided adequate relief.
At Holistic Wellness & Psychiatry, Ketamine-Assisted Psychotherapy (KAP) combines ketamine treatment with therapeutic support to help patients explore thoughts, emotions, and experiences that may be difficult to access through traditional therapy alone.
Ketamine may create a temporary state in which some patients experience greater openness, emotional flexibility, or a different perspective on their thoughts and experiences. Therapy provides a supportive space to reflect on these experiences and explore how they relate to your goals and ongoing wellbeing.
We encourage patients receiving ketamine treatment to have an established relationship with a therapist whenever possible. If you do not currently have a therapist, our team can help you explore appropriate therapy options. While psychotherapy is not required for ketamine treatment at Holistic Wellness & Psychiatry, we believe ongoing therapeutic support can be a valuable part of the overall treatment process.
Your treatment plan is tailored to your symptoms, medical history, treatment goals, and clinical needs. Our team will help you understand the available options and determine which approach may be appropriate for you.
An FDA-approved nasal treatment for specific indications, administered under medical supervision with required monitoring.
A clinician-supervised intravenous treatment that may be considered when traditional approaches have not provided adequate relief.
Combines ketamine treatment with psychotherapy to provide additional support for exploring thoughts, emotions, and experiences as part of your overall care.
When traditional medications and talk therapy alone haven't moved the needle, KAP offers a fundamentally different mechanism — and a different timeline.
High Efficacy
Short Treatment Course
Sustained Effect
Low Cost
Ketamine offers a different approach to mental health treatment, particularly for patients who have not experienced adequate relief from traditional approaches.
Ketamine works primarily through the brain's glutamate system, offering an alternative to traditional antidepressant approaches.
Some patients experience changes in symptoms sooner than with traditional antidepressants, though individual responses vary.
Ketamine may be provided through IV infusion or IM administration. SPRAVATO® is a separate FDA-approved nasal treatment for specific indications.
Ketamine can be combined with psychotherapy, medication management, and ongoing clinical support as part of an individualized treatment plan.
Our dedicated team of certified clinicians and mental health specialists provides safe, personalized Spravato® and ketamine treatments. In a comfortable, medically supervised environment, we are here to support your journey toward lasting relief and renewal.
Licensed Independent Social Worker specializing in trauma-informed therapy, EMDR, and Ketamine-Assisted Psychotherapy (KAP) integration, helping clients achieve deep healing and emotional empowerment through evidence-based, compassionate care.
Licensed mental health counselor trained in KAP, Internal Family Systems, and ART, supporting patients through mindful preparation, therapy sessions, and post-ketamine integration.
Board-Certified Physician Assistant specializing in integrative psychiatry, psychiatric medication management, and interventional treatments including Spravato® and ketamine therapy, dedicated to whole-person, collaborative care.
Board-Certified Psychiatric-Mental Health Nurse Practitioner providing comprehensive psychiatric assessments, personalized medication management, and interventional treatments including Spravato® and ketamine therapies.
Experienced psychiatric nurse practitioner specializing in mood disorders, trauma, and comprehensive mental health evaluations with a compassionate, root-cause focus.
Licensed Mental Health Counselor specializing in individual psychotherapy, trauma-informed care, and Ketamine-Assisted Psychotherapy (KAP) integration, supporting clients through compassionate and personalized healing journeys.
"All psychedelics have different mechanisms of action, but all lead to similar widespread brain wave synchrony — reducing entrenched beliefs and rigid thoughts that may have been adaptive in adolescence, but lead to stuckness and depression in adulthood."
Fifteen of the most common questions we get from new ketamine patients. Don’t see yours? Send us a message and we’ll answer within one business day.
KAP may be beneficial for individuals struggling with treatment-resistant depression, PTSD, anxiety, chronic stress, or other mental health conditions that haven’t responded to traditional treatments. The best way to determine if ketamine is right for you is through a comprehensive evaluation with our team.
Ketamine interacts with the brain’s glutamate system — a key player in mood regulation, cognition, and neuroplasticity. Unlike traditional antidepressants that take weeks to show effects, ketamine can provide rapid relief by blocking NMDA receptors and increasing the availability of neurotransmitters that promote healing and connection.
Nasal spray (Spravato and compounded racemic), intravenous (IV), or intramuscular (IM) — your provider will help you decide which is right.
Immediate: rapid improvement in mood, relief from depressive symptoms, and a feeling of relaxation or dissociation — lasting a few hours.
Short-term: a lingering sense of well-being or improved mood, lasting 24 hours to several days. Many feel more mentally clear, less anxious, or more energized.
Long-term: reductions in depressive symptoms can last 1–2 weeks, with some experiencing improvement for 4–6 weeks.
Some patients notice improvement after just one session, while others may need multiple treatments to experience full benefits.
Treatment length varies depending on the type of ketamine therapy, your treatment goals, and how you respond. Your clinician will recommend a treatment schedule based on your individual needs and monitor your progress throughout care.
Contact our office or fill out our New Patient Inquiry Form. Our team will guide you through the process and determine if ketamine therapy is right for you.
IV ketamine treatment is $500 per session, or $2,800 for a six-treatment induction series. For questions about payment options or treatment plans, please contact our office at (319) 800-2125.
SPRAVATO®: 2 hours · IV Ketamine: 45 min–1 hour · IM Ketamine: 45 min–1 hour
Yes. During ketamine treatment, you generally remain conscious and able to communicate, although you may experience relaxation, drowsiness, or changes in perception. Your care team will monitor you throughout the session.
We provide water, snacks, a blanket, eye mask, noise-canceling headphones, and a device to play music. If you want to bring anything else to make yourself more comfortable, please do.
In most cases, no. Before beginning treatment, we’ll review your medication list and work with your healthcare provider to determine the best approach. Please consult with our team before making any changes.
No — ketamine can cause drowsiness, dizziness, and impaired coordination. We strongly recommend arranging for a friend or family member to take you home after your session.
Download our ketamine referrals document to learn more about eligibility and the next steps for getting your patient evaluated.
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